Tissue imaging at atmospheric pressure using desorption electrospray ionization (DESI) mass spectrometry

被引：484

作者：

Wiseman, Justin M. ^{[1
]}

Ifa, Demian R. ^{[1
]}

Song, Qingyu ^{[1
]}

Cooks, R. Graham ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 43期

关键词：

lipids; mass spectrometry; microscopy; phospholipids; surface analysis;

D O I：

10.1002/anie.200602449

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Images of the masses: Two-dimensional molecular imaging of intact rat brain tissue under ambient conditions was achieved by using the mass spectrometric technique of desorption electrospray ionization (DESI). The distributions of specific lipids, such as sulfatide 24:1, reveal distinctive subanatomical features of the rat brain (cc = corpus callosum; aca = anterior part of anterior commissure) with spatial resolution of less than 500 μm. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7188 / 7192

页数：5

共 25 条

[1]

ARGONOFF BW, 1994, BASIC NEUROCHEMISTRY, P48

[2]

Benninghoven A., 1987, SECONDARY ION MASS S

[3] Molecular imaging of biological samples: Localization of peptides and proteins using MALDI-TOF MS [J].