Synthesis of homoallylic amines via the palladium-catalyzed decarboxylative coupling of amino acid derivatives

被引:134
作者
Burger, Erin C. [1 ]
Tunge, Jon A. [1 ]
机构
[1] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA
关键词
D O I
10.1021/ja063115x
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Protected homoallylic amines are synthesized by the decarboxylative coupling of α-amino acid derivatives. The catalytic C-C bond-forming reaction relies on the bioinspired decarboxylative metalation of α-amino acids to produce α-amino anion equivalents. The α-amino anion equivalents are intercepted by π-allyl palladium electrophiles to produce substituted homoallylic amines. Copyright © 2006 American Chemical Society.
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页码:10002 / 10003
页数:2
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