Enabling olefin metathesis on proteins: chemical methods for installation of S-allyl cysteine

被引：65

作者：

Chalker, Justin M. ^{[1
]}

Lin, Yuya A. ^{[1
]}

Boutureira, Omar ^{[1
]}

Davis, Benjamin G. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 25期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

CROSS-METATHESIS; REARRANGEMENT; PEPTIDES; BIOLOGY; SELENOSULFIDE; DISULFIDES; STRATEGIES; LIGATION; SULFIDES; THIOLS;

D O I：

10.1039/b908004j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multiple, complementary methods are reported for the chemical conversion of cysteine to S-allyl cysteine on protein surfaces, a useful transformation for the exploration of olefin metathesis on proteins.

引用

页码：3714 / 3716

页数：3

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