Genes influencing HDL metabolism: new perspectives and implications for atherosclerosis prevention

被引：39

作者：

Rader, DJ ^{[1
]}

Maugeais, C ^{[1
]}

机构：

[1] Univ Penn, Med Ctr, Prevent Cardiol & Lipid Res Ctr, Philadelphia, PA 19104 USA

来源：

MOLECULAR MEDICINE TODAY | 2000年 / 6卷 / 04期

关键词：

D O I：

10.1016/S1357-4310(00)01673-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atherosclerotic cardiovascular disease (ASCVD) is the most common cause of morbidity and mortality in Western societies. Current therapies, such as reduction of plasma cholesterol, significantly reduce, but do not come close to eliminating, the complications of ASCVD. Therefore, novel therapeutic approaches to the prevention of acute coronary events and progression of atherosclerosis are still needed. The complex metabolism of high density lipoproteins represents an attractive potential target for therapeutic intervention. Here, we will discuss those components of the high density lipoprotein metabolism and lipid transport pathways that are potential preventative or therapeutic targets for ASCVD.

引用

页码：170 / 175

页数：6

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