Prevention of diabetes in nonobese diabetic mice mediated by CD1d-restricted nonclassical NKT cells

被引：91

作者：

Duarte, N

Stenström, M

Campino, S

Bergman, ML

Lundholm, M

Holmberg, D

Cardell, SL ^{[1
]}

机构：

[1] Lund Univ, Ctr Biomed I13, Immunol Sect, S-22184 Lund, Sweden

[2] Umea Univ, Dept Med Biosci Med & Clin Genet, Umea, Sweden

[3] Gulbenkian Inst Sci, Oeiras, Portugal

[4] Norrland Univ Hosp, Dept Clin Genet, Umea, Sweden

来源：

JOURNAL OF IMMUNOLOGY | 2004年 / 173卷 / 05期

关键词：

D O I：

10.4049/jimmunol.173.5.3112

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A role for regulatory lymphocytes has been demonstrated in the pathogenesis of type I diabetes in the NOD mouse but the nature of these cells is debated. CD1d-restricted NKT lymphocytes have been implicated in this process. Previous reports of reduced diabetes incidence in NOD mice in which the numbers of NKT cells are artificially increased have been attributed to the enhanced production of IL-4 by these cells and a role for classical NKT cells, using the Valpha14-Jalpha18 rearrangement. We now show that overexpression in NOD mice of CD1d-restricted TCR Valpha3.2(+)Vbeta9(+) NKT cells producing high levels of IFN-gamma but low amounts of IL-4 leads to prevention of type 1 diabetes, demonstrating a role for nonclassical CD1d-restricted NKT cells in the regulation of autoimmune diabetes.

引用

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页码：3112 / 3118

页数：7

相关论文

共 39 条

[11] Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, αβ+ T cells [J].

Fritz, RB ;

Zhao, ML .

JOURNAL OF IMMUNOLOGY, 2001, 166 (06) :4209-4215

[12] Early quantitative and functional deficiency of NK1(+)-like thymocytes in the NOD mouse [J].

Gombert, JM ;

Herbelin, A ;

TancredeBohin, E ;

Dy, M ;

Carnaud, C ;

Bach, JF .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (12) :2989-2998

[13] Damage control, rather than unresponsiveness, effected by protective DX5+T cells in autoimmune diabetes [J].

Gonzalez, A ;

Andre-Schmutz, I ;

Carnaud, C ;

Mathis, D ;

Benoist, C .

NATURE IMMUNOLOGY, 2001, 2 (12) :1117-1125

[14] α/β-T cell receptor (TCR)+CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10 [J].

Hammond, KJL ;

Poulton, LD ;

Palmisano, LJ ;

Silveira, PA ;

Godfrey, DI ;

Baxter, AG .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (07) :1047-1056

[15] Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes [J].

Harrison, LC ;

DempseyCollier, M ;

Kramer, DR ;

Takahashi, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (06) :2167-2174

[16]

Herbelin A, 1998, J IMMUNOL, V161, P2620

[17] The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice [J].

Hong, S ;

Wilson, MT ;

Serizawa, I ;

Wu, L ;

Singh, N ;

Naidenko, OV ;

Miura, T ;

Haba, T ;

Scherer, DC ;

Wei, J ;

Kronenberg, M ;

Koezuka, Y ;

Van Kaer, L .

NATURE MEDICINE, 2001, 7 (09) :1052-1056

[18] THE TRANSFER OF AUTOIMMUNE DIABETES IN NOD MICE CAN BE INHIBITED OR ACCELERATED BY DISTINCT CELL-POPULATIONS PRESENT IN NORMAL SPLENOCYTES TAKEN FROM YOUNG MALES [J].

HUTCHINGS, PR ;

COOKE, A .

JOURNAL OF AUTOIMMUNITY, 1990, 3 (02) :175-185

[19] CD1d-restricted and TCR-mediated activation of V(alpha)14 NKT cells by glycosylceramides [J].

Kawano, T ;

Cui, JQ ;

Koezuka, Y ;

Toura, I ;

Kaneko, Y ;

Motoki, K ;

Ueno, H ;

Nakagawa, R ;

Sato, H ;

Kondo, E ;

Koseki, H ;

Taniguchi, M .

SCIENCE, 1997, 278 (5343) :1626-1629

[20]

Kukreja A, 2002, J CLIN INVEST, V109, P131, DOI 10.1172/JCI13605

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