The role of nutrition and chemoprevention in colorectal cancer: from observations to expectations

被引:9
作者
Vaisman, N
Arber, N
机构
[1] Tel Aviv Sourasky Med Ctr, Dept Gastroenterol, GI Oncol Unit, IL-64239 Tel Aviv, Israel
[2] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
[3] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
[4] Tel Aviv Sourasky Med Ctr, Dept Gastroenterol, Gastrointestinal Oncol Unit, Tel Aviv, Israel
关键词
nutrition; NSAIDs; specific COX-2 inhibitor; SAANDs; colorectal cancer; adenoma; apoptosis; chemoprevention;
D O I
10.1053/bega.2001.0281
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
During the last 20 years the role of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) in reducing the risk of colorectal cancer was shown in more than 100 animal studies. Support derives from 23 of 25 epidemiological studies confirming this protective effect. The COX-2 specific inhibitors and the selective apoptotic anti-neoplastic drugs offer the benefit of cancer protection without the gastrointestinal toxicity that was reported for the 'old' drugs. The presence of multiple molecular targets offers the potential for combination. The pivotal question in the puzzle of NSAID chemopreventive treatment should not be 'if' but 'how'. The concept that different food components may initiate or prevent cancer was illustrated by different epidemiological studies and animal models. Yet the chemical and biological complexity of the food, the difficulty in measuring habitual diets and the unavoidable changes in food constituents following a specific change in diet all contribute to this complexity.
引用
收藏
页码:201 / 217
页数:17
相关论文
共 95 条
[71]   Nonsteroidal anti-inflammatory drugs and colorectal cancer: Evolving concepts of their chemopreventive actions [J].
Shiff, SJ ;
Rigas, B .
GASTROENTEROLOGY, 1997, 113 (06) :1992-1998
[72]   Vitamin E and colon cancer: Is there an association? [J].
Slattery, ML ;
Edwards, SL ;
Anderson, K ;
Caan, B .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1998, 30 (03) :201-206
[73]  
Slattery ML, 2000, AM J CLIN NUTR, V71, P575
[74]   Use of nonsteroidal anti-inflammatory drugs and incidence of colorectal cancer -: A population-based study [J].
Smalley, W ;
Ray, WA ;
Daugherty, J ;
Griffin, MR .
ARCHIVES OF INTERNAL MEDICINE, 1999, 159 (02) :161-166
[75]   The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis [J].
Steinbach, G ;
Lynch, PM ;
Phillips, RKS ;
Wallace, MH ;
Hawk, E ;
Gordon, GB ;
Wakabayashi, N ;
Saunders, B ;
Shen, Y ;
Fujimura, T ;
Su, LK ;
Levin, B ;
Godio, L ;
Patterson, S ;
Rodriguez-Bigas, MA ;
Jester, SL ;
King, KL ;
Schumacher, M ;
Abbruzzese, J ;
DuBois, RN ;
Hittelman, WN ;
Zimmerman, S ;
Sherman, JW ;
Kelloff, G .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (26) :1946-1952
[76]   VEGETABLES, FRUIT, AND CANCER .2. MECHANISMS [J].
STEINMETZ, KA ;
POTTER, JD .
CANCER CAUSES & CONTROL, 1991, 2 (06) :427-442
[77]  
STEINMETZ KA, 1994, AM J EPIDEMIOL, V139, P1
[78]  
Strul H, 2000, ISR MED ASSOC J, V2, P695
[79]   Cyclooxygenase-2 inhibitors in tumorigenesis (Part I) [J].
Taketo, MM .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (20) :1529-1536
[80]   RISK-FACTORS FOR FATAL COLON CANCER IN A LARGE PROSPECTIVE-STUDY [J].
THUN, MJ ;
CALLE, EE ;
NAMBOODIRI, MM ;
FLANDERS, WD ;
COATES, RJ ;
BYERS, T ;
BOFFETTA, P ;
GARFINKEL, L ;
HEATH, CW .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1992, 84 (19) :1491-1500