A Stable Homodinuclear Biscobalt(III)-Schiff Base Complex for Catalytic Asymmetric 1,4-Addition Reactions of β-Keto Esters to Alkynones

被引：113

作者：

Chen, Zhihua ^{[1
]}

Furutachi, Makoto ^{[1
]}

Kato, Yuko ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

Shibasaki, Masakatsu ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 12期

关键词：

asymmetric catalysis; asymmetric synthesis; cobalt; conjugate addition; Schiff bases; NITROALDOL REACTIONS; CONJUGATE ADDITIONS;

D O I：

10.1002/anie.200805967

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Two metal cooperation: A homodinuclear Co2-Schiff base complex Co2(OAc)2-1 promoted the asymmetric 1,4-addition of β-keto esters to alkynones under solvent-free conditions in air (see scheme). The reactions proceeded without air or moisture sensitivity in high yields and with high enantioselectivities (99-91% ee) at room temperature under highly concentrated conditions (neat-20 M) with 0.1-2.5 mol % catalyst loading. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2218 / 2220

页数：3

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