On the optimal energy of epithermal neutron beams for BNCT

被引：32

作者：

Bisceglie, E ^{[1
]}

Colangelo, P

Colonna, N

Santorelli, P

Variale, V

机构：

[1] Ist Nazl Fis Nucl, Sez Bari, I-70123 Bari, Italy

[2] Univ Naples Federico II, Dipartimento Sci Fisiche, I-80125 Naples, Italy

[3] Ist Nazl Fis Nucl, I-80125 Naples, Italy

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2000年 / 45卷 / 01期

关键词：

D O I：

10.1088/0031-9155/45/1/304

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The optimal neutron energy for the treatment of deep-seated rumours using boron neutron capture therapy is studied by analysing various figures of merit. In particular, analysis of the therapeutic gain as a function of the neutron energy indicates that, with the currently available B-10 carriers, the most useful neutrons for the treatment of deep-seated rumours, in particular glioblastoma multiforme. are those with an energy of a few keV. Based on the results of the simulations, a method is presented which allows us to evaluate the quality of epithermal neutron beams of known energy spectrum, thus allowing us to compare different neutron-producing reactions and beam-shaping assembly configurations used for accelerator-based neutron sources.

引用

页码：49 / 58

页数：10

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