Highly enantioselective hydrosilylation of aromatic alkenes

被引：112

作者：

Jensen, JF ^{[1
]}

Svendsen, BY ^{[1
]}

la Cour, TV ^{[1
]}

Pedersen, HL ^{[1
]}

Johannsen, M ^{[1
]}

机构：

[1] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 17期

关键词：

D O I：

10.1021/ja025617q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Currently, the most effective and economic way to convert an alkene into an optically active alcohol is the two-step sequence: hydrosilylation/oxidation. Much work has been devoted to elucidating effective catalysts for this process, but hitherto only one effective and highly stereoselective process has been available. Herein we present a novel catalytic system for the asymmetric hydrosilylation of aromatic alkenes, giving the products in high yields and with the highest enantioselectivity (up to 99% ee) ever observed for this reaction. The reaction works efficiently for a variety of substituted aromatic alkenes, giving access after Tamao oxidation to almost optically pure benzylic alcohols in high yields. Copyright © 2002 American Chemical Society.

引用

页码：4558 / 4559

页数：2

共 36 条

[1] Atropo-enantioselective synthesis of an axially chiral C1-symmetric phosphine ligand and its application in the asymmetric hydrosilylation of styrenes [J].