Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles

被引：1159

作者：

Asati, Atul ^{[1
,2
]}

Santra, Santimukul ^{[1
,2
]}

Kaittanis, Charalambos ^{[1
,2
]}

Nath, Sudip ^{[1
,2
]}

Perez, J. Manuel ^{[1
,2
]}

机构：

[1] Univ Cent Florida, Nanosci Technol Ctr, Dept Chem, Orlando, FL 32826 USA

[2] Univ Cent Florida, Burnett Coll Biomed Sci, Orlando, FL 32826 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 13期

基金：

美国国家卫生研究院;

关键词：

cerium; immunoassays; nanotechnology; oxidases; oxidation; CLICK CHEMISTRY; CATALYSIS;

D O I：

10.1002/anie.200805279

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2308 / 2312

页数：5

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