Differentiation of atypical parkinsonian syndromes with routine MRI

被引:314
作者
Schrag, A
Good, CD
Miszkiel, K
Morris, HR
Mathias, CJ
Lees, AJ
Quinn, NP
机构
[1] Inst Neurol, Dept Clin Neurol, London WC1 3BG, England
[2] Inst Neurol, Dept Neuroradiol, London WC1 3BG, England
[3] Inst Neurol, Autonom Unit, London WC1 3BG, England
关键词
progressive supranuclear palsy; multiple system atrophy; corticobasal degeneration; MRI; diagnosis;
D O I
10.1212/WNL.54.3.697
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To evaluate the use of routine MRI in differentiating between patients with progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD) and control subjects. Methods: Two neuroradiologists rated blindly and independently axial TX-weighted and proton density MR images of 54 patients with MSA, 35 patients with PSP, 5 patients with CBD, and 44 control subjects. Results: More than 70% of patients with PSP and more than 80% of patients with cerebellar predominant MSA could be classified correctly with 0.5-T or 1.5-T scans, and no patient in these groups was misclassified. In the remaining patients an unequivocal differentiation could not be made. However, only approximately 50% of patients with parkinsonism-predominant MSA could be classified correctly, and 19% of them (all of whom had had 0.5-T scans) were misclassified. Conclusions: Characteristic findings on routine MRI, either 1.5 T or 0.5 T, can contribute to the identification of MSA and PSP. However, in a minority of patients no unequivocal diagnosis can be made using MRI findings alone.
引用
收藏
页码:697 / 702
页数:6
相关论文
共 19 条
[1]   RELATIONSHIP BETWEEN LEVODOPA-INDEPENDENT SYMPTOMS AND CENTRAL ATROPHY EVALUATED BY MAGNETIC-RESONANCE-IMAGING IN PARKINSONS-DISEASE [J].
DURIF, F ;
POLLAK, P ;
HOMMEL, M ;
ARDOUIN, C ;
LEBAS, JF ;
CROUZET, G ;
PERRET, J .
EUROPEAN NEUROLOGY, 1992, 32 (01) :32-36
[2]   PREVALENCE AND NATURAL-HISTORY OF PROGRESSIVE SUPRANUCLEAR PALSY [J].
GOLBE, LI ;
DAVIS, PH ;
SCHOENBERG, BS ;
DUVOISIN, RC .
NEUROLOGY, 1988, 38 (07) :1031-1034
[3]   Magnetic resonance imaging of corticobasal degeneration [J].
Hauser, RA ;
Murtaugh, FR ;
Akhter, K ;
Gold, M ;
Olanow, CW .
JOURNAL OF NEUROIMAGING, 1996, 6 (04) :222-226
[4]   WHAT FEATURES IMPROVE THE ACCURACY OF CLINICAL-DIAGNOSIS IN PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY [J].
HUGHES, AJ ;
BENSHLOMO, Y ;
DANIEL, SE ;
LEES, AJ .
NEUROLOGY, 1992, 42 (06) :1142-1146
[5]   The combination of hypointense and hyperintense signal changes on T2-weighted magnetic resonance imaging sequences -: A specific marker of multiple system atrophy? [J].
Kraft, E ;
Schwarz, J ;
Trenkwalder, C ;
Vogl, T ;
Pfluger, T ;
Oertel, WH .
ARCHIVES OF NEUROLOGY, 1999, 56 (02) :225-228
[6]   MEASUREMENT OF OBSERVER AGREEMENT FOR CATEGORICAL DATA [J].
LANDIS, JR ;
KOCH, GG .
BIOMETRICS, 1977, 33 (01) :159-174
[7]  
Lees AJ, 1987, MOVEMENT DISORD, V2, P272
[8]   Accuracy of the clinical diagnosis of corticobasal degeneration: A clinicopathologic study [J].
Litvan, I ;
Agid, Y ;
Goetz, C ;
Jankovic, J ;
Wenning, GK ;
Brandel, JP ;
Lai, EC ;
Verny, M ;
RayChaudhuri, K ;
McKee, A ;
Jellinger, K ;
Pearce, RKB ;
Bartko, JJ .
NEUROLOGY, 1997, 48 (01) :119-125
[9]   What is the accuracy of the clinical diagnosis of multiple system atrophy? A clinicopathologic study [J].
Litvan, I ;
Goetz, CG ;
Jankovic, J ;
Wenning, GK ;
Booth, V ;
Bartko, JJ ;
McKee, A ;
Jellinger, K ;
Lai, EC ;
Brandel, JP ;
Verny, M ;
Chaudhuri, KR ;
Pearce, RKB ;
Agid, Y .
ARCHIVES OF NEUROLOGY, 1997, 54 (08) :937-944
[10]   Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): Report of the NINDS-SPSP International Workshop [J].
Litvan, I ;
Agid, Y ;
Calne, D ;
Campbell, G ;
Dubois, B ;
Duvoisin, RC ;
Goetz, CG ;
Golbe, LI ;
Grafman, J ;
Growdon, JH ;
Hallett, M ;
Jankovic, J ;
Quinn, NP ;
Tolosa, E ;
Zee, DS ;
Chase, TN ;
FitzGibbon, EJ ;
Hall, Z ;
Juncos, J ;
Nelson, KB ;
Oliver, E ;
Pramstaller, P ;
Reich, SG ;
Verny, M .
NEUROLOGY, 1996, 47 (01) :1-9