Peroxynitrite signaling: Receptor tyrosine kinases and activation of stress-responsive pathways

被引：96

作者：

Klotz, LO ^{[1
]}

Schroeder, P ^{[1
]}

Sies, H ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Physiol Chem 1, D-40001 Dusseldorf, Germany

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2002年 / 33卷 / 06期

关键词：

stress signaling; signal transduction; reactive oxygen species; reactive nitrogen species;

D O I：

10.1016/S0891-5849(02)00892-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxynitrite, generated for example in inflammatory processes, is capable of nitrating and oxidizing biomolecules, implying a considerable impact on the integrity of cellular structures. Cells respond to stressful conditions by the activation of signaling pathways, including receptor tyrosine kinase-dependent pathways such as mitogen-activated protein kinases and the phosphoinositide-3-kinase/Akt pathway. Peroxynitrite affects signaling pathways by nitration as well as by oxidation: while nitration of tyrosine residues by peroxynitrite modulates signaling processes relying on tyrosine phosphorylation and dephosphorylation, oxidation of phosphotyrosine phosphatases may lead to an alteration in the tyrosine phosphorylation/dephosphorylation balance. The flavanol (-)-epicatechin is a potent inhibitor of tyrosine nitration and may be employed as a tool to distinguish signaling effects due to tyrosine nitration from those that are due to oxidation reactions. (C) 2002 Elsevier Science Inc.

引用

页码：737 / 743

页数：7

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