CtIP, a multivalent adaptor connecting transcriptional regulation, checkpoint control and tumor suppression

被引：24

作者：

Wu, Guikai ^{[1
]}

Lee, Wen-Hwa ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92697 USA

来源：

CELL CYCLE | 2006年 / 5卷 / 15期

关键词：

CtIP; Rb/E2F pathway; checkpoint; tumor suppression; review;

D O I：

10.4161/cc.5.15.3127

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CtIP was originally characterized as an interacting protein for the transcriptional corepressor CtBP. In addition to transcriptional regulation, CtIP plays an important role in the DNA damage response and cell cycle checkpoint control. Recent evidence points to a viral factor-like S phase promoting activity of CtIP in counteracting Rb repression to facilitate E2F-directed transactivation during the G(1)/S transition. Genetic studies in mice revealed the haploid insufficiency of CtIP in suppressing tumorigenesis associated with shortened life span. Thus, CtIP emerges as a multivalent adaptor that connects cell cycle checkpoint control, transcriptional regulation and tumor suppression.

引用

页码：1592 / 1596

页数：5

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