Synthetic studies on the rhizoxins .2. An approach to the C-10-C-26 subunit using ''substrate directed'' allylstannane additions to aldehydes.

被引：29

作者：

Keck, GE

Savin, KA

Weglarz, MA

Cressman, ENK

机构：

[1] Department of Chemistry, University of Utah, Salt Lake City

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 19期

关键词：

D O I：

10.1016/0040-4039(96)00578-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The construction of a C-10-C-26 fragment of the 16-membered antitumor macrolide rhizoxin has been achieved in an efficient manner. The central portion of this molecule has been prepared in enantiopure form via an iterative allylstannylation protocol starting with the ester of (R)-lactic acid. The oxazole portion of rhizoxin was attached via a samarium diiodide modified Julia coupling to generate the requisite all E triene. (C) 1996 Elsevier Science Ltd.

引用

页码：3291 / 3294

页数：4