Cytoplasmic functions of the tumour suppressor p53

被引：893

作者：

Green, Douglas R. ^{[1
]}

Kroemer, Guido ^{[2
,3
]}

机构：

[1] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

[2] Inst Gustave Roussy, INSERM, U848, F-94805 Villejuif, France

[3] Univ Paris Sud, Paris 11, France

来源：

NATURE | 2009年 / 458卷 / 7242期

关键词：

MITOCHONDRIAL-MEMBRANE PERMEABILIZATION; CELL-DEATH; BCL-XL; APOPTOSIS; AUTOPHAGY; ACTIVATION; TRANSLOCATION; NUCLEAR; ABSENCE; GENES;

D O I：

10.1038/nature07986

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The principal tumour-suppressor protein, p53, accumulates in cells in response to DNA damage, oncogene activation and other stresses. It acts as a nuclear transcription factor that transactivates genes involved in apoptosis, cell cycle regulation and numerous other processes. An emerging area of research unravels additional activities of p53 in the cytoplasm, where it triggers apoptosis and inhibits autophagy. These previously unknown functions contribute to the mission of p53 as a tumour suppressor.

引用

页码：1127 / 1130

页数：4

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