Dual role for phenylalanine 178 during catalysis by aristolochene synthase

被引：24

作者：

Forcat, S ^{[1
]}

Allemann, RK ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 18期

关键词：

D O I：

10.1039/b407932a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mutant of aristolochene synthase, in which Phe 178 was replaced by Val, produced significant amounts of alpha- and beta-farnesene as well as alpha and beta-selinene and selina-4,11-diene, suggesting that Phe 178 is involved in the stabilisation of transition states preceding germacrene A and following eudesmane cation.

引用

页码：2094 / +

页数：2

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