Sniffing a human sex-steroid derived compound affects mood and autonomic arousal in a dose-dependent manner

被引：51

作者：

Bensafi, M

Tsutsui, T

Khan, R

Levenson, RW

Sobel, N

机构：

[1] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Psychol, Berkeley, CA 94720 USA

来源：

PSYCHONEUROENDOCRINOLOGY | 2004年 / 29卷 / 10期

关键词：

olfaction; mood; autonomic nervous system; dose-response; androstadienone; pheromones;

D O I：

10.1016/j.psyneuen.2004.03.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of sniffing different concentrations of the human sex-steroid derived compound 4,16-androstadien-3-one (AND) on autonomic nervous system function and mood were measured in 60 subjects. The effects were sex-specific and concentration-dependent. Only high concentrations of AND (0.00625 M) increased positive mood (p < 0.03) and decreased negative mood (p < 0.05) in women compared to men, and had sympathetic-like effects in women (p < 0.003), and parasympathetic-like effects in men (p < 0.05). These findings further implicate AND in chemical communication between humans, but pose questions as to the path by which AND is transduced, whether through chemical sensing or transdermal diffusion. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1290 / 1299

页数：10

相关论文

共 72 条

[1] Odor hedonics: Connection with emotional response estimated by autonomic parameters [J].

AlaouiIsmaili, O ;

VernetMaury, E ;

Dittmar, A ;

Delhomme, G ;

Chanel, J .

CHEMICAL SENSES, 1997, 22 (03) :237-248

[2] Effect of vomeronasal organ removal on male socio-sexual responses to female in a prosimian primate (Microcebus murinus) [J].

Aujard, F .

PHYSIOLOGY & BEHAVIOR, 1997, 62 (05) :1003-1008

[3]

Beckman M, 2002, SCIENCE, V295, P782

[4] Influence of affective and cognitive judgments on autonomic parameters during inhalation of pleasant and unpleasant odors in humans [J].

Bensafi, M ;

Rouby, C ;

Farget, V ;

Bertrand, B ;

Vigouroux, M ;

Holley, A .

NEUROSCIENCE LETTERS, 2002, 319 (03) :162-166

[5] Autonomic nervous system responses to odours: the role of pleasantness and arousal [J].

Bensafi, M ;

Rouby, C ;

Farget, V ;

Bertrand, B ;

Vigouroux, M ;

Holley, A .

CHEMICAL SENSES, 2002, 27 (08) :703-709

[6] Sex-steroid derived compounds induce sex-specific effects on autonomic nervous system function in humans [J].

Bensafi, M ;

Brown, WM ;

Tsutsui, T ;

Mainland, JD ;

Johnson, BN ;

Bremner, EA ;

Young, N ;

Mauss, I ;

Ray, B ;

Gross, J ;

Richards, J ;

Stappen, I ;

Levenson, RW ;

Sobel, N .

BEHAVIORAL NEUROSCIENCE, 2003, 117 (06) :1125-1134

[7] Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs [J].

Berghard, A ;

Buck, LB ;

Liman, ER .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) :2365-2369

[8] The functionality of the human vomeronasal organ (VNO): Evidence for steroid receptors [J].

Berliner, DL ;

MontiBloch, L ;

JenningsWhite, C ;

DiazSanchez, V .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1996, 58 (03) :259-265

[9] Pheromone detection in rodents [J].

Biasi, E ;

Silvotti, L ;

Tirindelli, R .

NEUROREPORT, 2001, 12 (14) :A81-A84

[10] ELECTROCORTICAL AND AUTONOMIC ALTERATION BY ADMINISTRATION OF A PLEASANT AND AN UNPLEASANT ODOR [J].

BRAUCHLI, P ;

RUEGG, PB ;

ETZWEILER, F ;

ZEIER, H .

CHEMICAL SENSES, 1995, 20 (05) :505-515

← 1 2 3 4 5 6 7 8 →