Contact in the genetics of autism and schizophrenia

被引：126

作者：

Burbach, J. Peter H. ^{[1
]}

van der Zwaag, Bert ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Neurosci & Pharmacol, Rudolf Magnus Inst Neurosci, NL-3508 AB Utrecht, Netherlands

来源：

TRENDS IN NEUROSCIENCES | 2009年 / 32卷 / 02期

关键词：

LA-TOURETTE-SYNDROME; SPECTRUM DISORDERS; CNTNAP2; GENE; ASSOCIATION; RISK; CONTACTIN-ASSOCIATED-PROTEIN-LIKE-2; REARRANGEMENTS; DISRUPTION; PHENOTYPES; EPILEPSY;

D O I：

10.1016/j.tins.2008.11.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although autism and schizophrenia are considered to be distinct neuropsychiatric developmental disorders, recent studies indicate that they share genetic factors. The same chromosomal rearrangements and several single genes have emerged as genetic risks in both disorders. One such gene is contactin-associated protein-2 (CNTNAP2). These findings raise the possibility that these neuropsychiatric disorders share pathogenic mechanisms and that similar defects in biological pathways of brain development might underlie the phenotypic spectrum of these disorders.

引用

页码：69 / 72

页数：4

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