Plaques, tangles, and memory loss in mouse models of neurodegeneration

被引:107
作者
Eriksen, Jason L. [1 ]
Janus, Christopher G. [1 ]
机构
[1] Mayo Clin Jacksonville, Dept Neurosci, Jacksonville, FL 32224 USA
关键词
Alzheimer's disease; tauopathy; dementia; transgenic mouse models;
D O I
10.1007/s10519-006-9118-z
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Within the past decade, our understanding of the pathogenic mechanisms in Alzheimer's disease (AD) has dramatically advanced because of the development of transgenic mouse models that recapitulate the key pathological and behavioral phenotypes of the disease. These mouse models have allowed investigators to test detailed questions about how pathology develops and to evaluate potential therapeutic approaches that could slow down the development of this disease. In this review, we discuss the status of transgenic mouse models and review the complex relationship between pathology and behavior in the development of neuropathological syndromes in AD.
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收藏
页码:79 / 100
页数:22
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