Nampt: linking NAD biology, metabolism and cancer

被引：330

作者：

Garten, Antje ^{[1
]}

Petzold, Stefanie ^{[1
]}

Koerner, Antje ^{[1
]}

Imai, Shin-ichiro ^{[2
]}

Kiess, Wieland ^{[1
]}

机构：

[1] Univ Leipzig, Hosp Children & Adolescents, Res Lab, D-04317 Leipzig, Germany

[2] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2009年 / 20卷 / 03期

关键词：

COLONY-ENHANCING FACTOR; NICOTINAMIDE ADENINE-DINUCLEOTIDE; PLASMA VISFATIN CONCENTRATIONS; STIMULATED INSULIN-SECRETION; SERUM VISFATIN; INCREASED DOSAGE; VISCERAL FAT; BETA-CELLS; LIFE-SPAN; SIR2;

D O I：

10.1016/j.tem.2008.10.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD) intermediate. Previously identified as a cytokine pre-B-cell colony-enhancing factor and controversially claimed as an insulin-mimetic hormone visfatin, Nampt has recently drawn much attention in several fields, including NAD biology, metabolism and inflammation. As a NAD biosynthetic enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins and influences a variety of metabolic and stress responses. Nampt also plays an important part in regulating insulin secretion in pancreatic beta-cells. Nampt seems to have another function as an immunomodulatory cytokine and, therefore, has a role in inflammation. This review summarizes these various functional aspects of Nampt and discusses its potential roles in diseases, including type 2 diabetes and cancer.

引用

页码：130 / 138

页数：9

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