Convenient enantioselective synthesis of new 1,4-sulfanyl alcohols from γ-lactones

被引：12

作者：

Filippi, JJ ^{[1
]}

Fernandez, X ^{[1
]}

Lizzani-Cuvelier, L ^{[1
]}

Loiseau, AM ^{[1
]}

机构：

[1] Univ Nice, Lab Aromes Sytheses Interact, F-06108 Nice 2, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 35期

关键词：

1,4-sulfanylalcohols; gamma-lactones; enzymatic resolution; thionation reaction; reduction;

D O I：

10.1016/S0040-4039(02)01268-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic strategy based upon three basic reactions-enzymatic resolution, oxygen-sulfur exchange, reduction-allowed us to carry out an easy and useful synthesis of a series of new 1,4-sulfanylalcohols from aliphatic gamma-lactones. Final products have been obtained in good yields with enantiomeric excesses in a 66-91% range. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6267 / 6270

页数：4

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