Lipase-catalysed resolution of gamma- and delta-lactones

被引：28

作者：

Enzelberger, MM

Bornscheuer, UT

Gatfield, I

Schmid, RD

机构：

[1] UNIV STUTTGART,INST TECH BIOCHEM,D-70569 STUTTGART,GERMANY

[2] HAARMANN & REIMER GMBH,D-37603 HOLZMINDEN,GERMANY

来源：

JOURNAL OF BIOTECHNOLOGY | 1997年 / 56卷 / 02期

关键词：

lactones; lipase; Pseudomonas species; stereoselective hydrolysis;

D O I：

10.1016/S0168-1656(97)00107-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lipase-catalysed stereoselective hydrolysis of a family of saturated gamma- and delta-lactones was investigated. Increasing the chain length from delta-octalactone to delta-dodecalactone leads to higher enantiomeric excess. Best results were found using a lipase from Pseudomonas species (KW51) yielding highest enantiomeric excesses (greater than 99%ee at 50% conversion, E>100) at short reaction times (10 h) for delta-undecalactone and delta-dodecalactone. In contrast, gamma-lactones were resolved less efficiently. Highest enantioselectivities (70%ee at 50% conversion, E=11) were found for gamma-nonalactone. Optimum reaction conditions were found at pH 8 and 12.5 degrees C. (C) 1997 Elsevier Science B.V.

引用

收藏

页码：129 / 133

页数：5

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