Chronic treatment with phentermine combined with fenfluramine lowers plasma serotonin

被引：37

作者：

Rothman, RB ^{[1
]}

Redmon, JB ^{[1
]}

Raatz, SK ^{[1
]}

Kwong, CA ^{[1
]}

Swanson, JE ^{[1
]}

Bantle, JP ^{[1
]}

机构：

[1] Univ Minnesota, Gen Clin Res Ctr, Dept Med, Div Endocrinol & Diabet, Minneapolis, MN USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2000年 / 85卷 / 07期

关键词：

D O I：

10.1016/S0002-9149(99)00896-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

As expected on the basis of published research in both humans and animals, treatment with phentermine/fenfluramine lowers plasma 5-hydroxytryptophan whereas treatment with phentermine had no significant effect. In light of these findings, future research should focus on mechanisms other than increased plasma 5-hydroxytryptophan to explain how fenfluramine increases the risk of primary pulmonary hypertension and valvular heart disease.

引用

页码：913 / +

页数：4