Contribution of Candida albicans ALS1 to the pathogenesis of experimental oropharyngeal candidiasis

被引：63

作者：

Kamai, Y

Kubota, M

Kamai, Y

Hosokawa, T

Fukuoka, T

Filler, SG

机构：

[1] Sankyo Co Ltd, Biol Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

[2] Sankyo Co Ltd, Lab Anim Sci & Toxicol Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

[3] Harbor UCLA Res & Educ Inst, Torrance, CA 90502 USA

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 09期

关键词：

D O I：

10.1128/IAI.70.9.5256-5258.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the contribution of Candida albicans ALS1, which encodes a candidal adhesin, to the pathogenesis of experimental murine oropharyngeal candidiasis. Our results indicate that the ALS1 gene product is important for the adherence of the organism to the oral mucosa during the early stage of the infection.

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收藏

页码：5256 / 5258

页数：3

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