Long-chain n-3-to-n-6 polyunsaturated fatty acid ratios in breast adipose tissue from women with and without breast cancer

被引:76
作者
Bagga, D
Anders, KH
Wang, HJ
Glaspy, JA [1 ]
机构
[1] Univ Calif Los Angeles, Div Hematol Oncol, Dept Med, Sch Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Sch Med, Dept Biomath, Los Angeles, CA 90095 USA
[3] Kaiser Hosp, Woodland Hills, CA 91365 USA
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2002年 / 42卷 / 02期
关键词
D O I
10.1207/S15327914NC422_5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Animal studies suggest that dietary polyunsaturated fatty acids (PUFAs) of the n-6 class, found in corn and safflower oils, may be precursors of intermediates involved in the development of mammary tumors, whereas long-chain (LC) n-3 PUFAs, found in fish oil, can inhibit these effects. This case-control study was designed to examine the relationship between the PUFA composition of breast adipose tissue and the risk of breast cancer. Using fatty acid levels in breast adipose tissue as a biomarker of past qualitative dietary intake of fatty acids, we examined the hypothesis that breast cancer risk is negatively associated with specific LC n-3 PUFAs (eicosapentaenoic acid and docosahexaenoic acid) and positively associated with n-6 PUFAs (linoleic acid and arachidonic acid). Breast adipose tissue was collected from 73 breast cancer patients and 74 controls with macromastia. The fatty acid levels were determined by gas-liquid chromatography. A logistic regression model was used to obtain odds ratio estimates while adjusting for age. The age-adjusted n-6 PUFA ((linoleic acid and arachidonic acid) content was significantly higher in cases than in controls (P = 0.02). There was a trend in the age-adjusted data suggesting that, at a given level of n-6 PUFA, LC n-3 PUFAs (eicosapentaenoic acid and docosahexaenoic acid) may have a protective effect (P = 0.06). A similar inverse relationship was observed with LC n-3-to-n-6 ratio when the data were adjusted for age (P = 0.09). We conclude that total n-6 PUFAs may be contributing to the high risk of breast cancer in the United States and that LC n-3 PUFAs, derived from fish oils, may have a protective effect.
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页码:180 / 185
页数:6
相关论文
共 38 条
[1]  
[Anonymous], BREAST CANC
[2]   The effect of dietary n-3 and n-6 polyunsaturated fatty acids on the expression of cyclooxygenase 1 and 2 and levels of p21ras in rat mammary glands [J].
Badawi, AF ;
El-Sohemy, A ;
Stephen, LL ;
Ghoshal, AK ;
Archer, MC .
CARCINOGENESIS, 1998, 19 (05) :905-910
[3]   Dietary modulation of omega-3-omega-6 polyunsaturated fatty acid ratios in patients with breast cancer [J].
Bagga, D ;
Capone, S ;
Wang, HJ ;
Heber, D ;
Lill, M ;
Chap, L ;
Glaspy, JA .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (15) :1123-1131
[4]   Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers [J].
Bartsch, H ;
Nair, J ;
Owen, RW .
CARCINOGENESIS, 1999, 20 (12) :2209-2218
[5]   MATHEMATICAL RELATIONSHIP BETWEEN THE FATTY-ACID COMPOSITION OF THE DIET AND THAT OF THE ADIPOSE-TISSUE IN MAN [J].
BEYNEN, AC ;
HERMUS, RJJ ;
HAUTVAST, JGAJ .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1980, 33 (01) :81-85
[6]  
BIRT DF, 1990, NUTR REV, V48, P1, DOI 10.1111/j.1753-4887.1990.tb02870.x
[7]   EICOSANOIDS AND LINOLEATE-ENHANCED GROWTH OF MOUSE MAMMARY-TUMOR CELLS [J].
BUCKMAN, DK ;
HUBBARD, NE ;
ERICKSON, KL .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1991, 44 (03) :177-184
[8]  
CALEFFI M, 1987, ANTICANCER RES, V7, P1305
[9]   Omega-3 polyunsaturated fatty acids in rodent models of breast cancer [J].
Cave, WT .
BREAST CANCER RESEARCH AND TREATMENT, 1997, 46 (2-3) :239-246
[10]   INHIBITION OF PROSTAGLANDIN BIOSYNTHESIS BY EICOSAPENTAENOIC ACID [J].
CULP, BR ;
TITUS, BG ;
LANDS, WEM .
PROSTAGLANDINS AND MEDICINE, 1979, 3 (05) :269-278