Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists

被引：41

作者：

Chesworth, R ^{[1
]}

Zawistoski, MP ^{[1
]}

Lefker, BA ^{[1
]}

Cameron, KO ^{[1
]}

Day, RF ^{[1
]}

Mangano, M ^{[1
]}

Rosati, RL ^{[1
]}

Colella, S ^{[1
]}

Petersen, DN ^{[1
]}

Brault, A ^{[1
]}

Lu, BH ^{[1
]}

Pan, LC ^{[1
]}

Perry, P ^{[1
]}

Ng, O ^{[1
]}

Castleberry, TA ^{[1
]}

Owen, TA ^{[1
]}

Brown, TA ^{[1
]}

Thompson, DD ^{[1
]}

DaSilva-Jardine, P ^{[1
]}

机构：

[1] Pfizer Inc, Global Res & Dev, CVMD Groton Labs, Groton, CT 06340 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 11期

关键词：

tetrahydroisoquinolines; ER alpha; ER beta;

D O I：

10.1016/j.bmcl.2004.03.077

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two series of 6-hydroxy and 7-hydroxy tetrahydroisoquinolines were prepared. Evaluating a range of C-1, C-4, and N-substituents led to the discovery of ER alpha and ER beta selective analogs. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2729 / 2733

页数：5

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