New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells

被引：143

作者：

Gao, JJ

Min, BS

Ahn, EM

Nakamura, N

Lee, HK

Hattori, M

机构：

[1] Toyama Med & Pharmaceut Univ, Inst Nat Med, Toyama 9300194, Japan

[2] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 06期

关键词：

lucialdehyde A-C; lanostane-type triterpene aldehyde; Ganoderma lucidum; cytotoxicity;

D O I：

10.1248/cpb.50.837

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new lanostante-type triterpene aldehydes, named lucialdehydes A-C (1-3), were isolated from the fruiting bodies of Ganoderma lucidum, together with ganodermanonol (4), ganodermadiol (5), ganodermanondiol (6), ganodermanontriol (7), ganoderic acid A (8), ganoderic acid B8 (9), and ganoderic acid Cl (10). The structures of the new triterpenes were determined as (24E)-3beta-hydroxy-5alpha-lanosta-7,9(11),24-trien-26-al (1), (24E)-3,7-dioxo-5alpha-lanosta-8,24-dien-26-al (2), and (24E)-3beta-hydroxy-7-oxo-5alpha-lanosta-8,24-dien-26-al (3), respectively, by spectroscopic means. The cytotoxicity of the compounds isolated from the ganoderma mushroom was tested in vitro against Lewis lung carcinoma (LLC), T-47D, Sarcoma 180, and Meth-A tumor cell lines. Lucialdehydes B, C (2, 3), ganodermanonol (4) and ganodermanondiol (6) showed cytotoxic effects on tested tumor cells. Of the compounds, lucialdehyde C (3) exhibited the most potent cytotoxicity against LLC, T-47D, Sarcoma 180, and Meth-A tumor cells with ED50 values of 10.7, 4.7, 7.1, and 3.8 mug/ml, respectively.

引用

页码：837 / 840

页数：4

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