Outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy
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Sliwa, K
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Univ Witwatersrand, Chris Hani Baragwanath Hosp, Dept Cardiol, Johannesburg, South AfricaUniv Witwatersrand, Chris Hani Baragwanath Hosp, Dept Cardiol, Johannesburg, South Africa
Sliwa, K
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Forster, O
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Univ Witwatersrand, Chris Hani Baragwanath Hosp, Dept Cardiol, Johannesburg, South AfricaUniv Witwatersrand, Chris Hani Baragwanath Hosp, Dept Cardiol, Johannesburg, South Africa
Forster, O
[1
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Zhanje, F
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Univ Witwatersrand, Chris Hani Baragwanath Hosp, Dept Cardiol, Johannesburg, South AfricaUniv Witwatersrand, Chris Hani Baragwanath Hosp, Dept Cardiol, Johannesburg, South Africa
Zhanje, F
[1
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Candy, G
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Kachope, J
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Univ Witwatersrand, Chris Hani Baragwanath Hosp, Dept Cardiol, Johannesburg, South AfricaUniv Witwatersrand, Chris Hani Baragwanath Hosp, Dept Cardiol, Johannesburg, South Africa
Kachope, J
[1
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Essop, R
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Univ Witwatersrand, Chris Hani Baragwanath Hosp, Dept Cardiol, Johannesburg, South AfricaUniv Witwatersrand, Chris Hani Baragwanath Hosp, Dept Cardiol, Johannesburg, South Africa
Essop, R
[1
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机构:
[1] Univ Witwatersrand, Chris Hani Baragwanath Hosp, Dept Cardiol, Johannesburg, South Africa
Subsequent pregnancy in 6 patients with, previous peripartum cardiomyopathy resulted in reduction of ejection fraction by >10% in 5 patients at 1 month postportum. Two patients with impaired ejection fraction at onset of subsequent pregnancy died 3 months postpartum-due to heart failure despite optimal medical therapy. Deterioration of left ventricular function occurred uniformly postpartum and was accompanied by elevation of tumor necrosis factor-a plasma levels from 2.4 +/- 1.1 pg/ml at onset of subsequent pregnancy to 6.2 +/- 2.4 pg/ml at 1 month postpartum. (C)2004 by Excerpta Medica, Inc.