Toll-like receptor pathways in the immune responses to mycobacteria

被引：217

作者：

Quesniaux, V

Fremond, C

Jacobs, M

Parida, C

Nicolle, D

Yeremeev, V

Bihl, F

Erard, F

Botha, T

Drennan, M

Soler, MN

Le Bert, M

Schnyder, B

Ryffel, E

机构：

[1] CNRS, Inst Transgenose, F-45071 Orleans, France

[2] Univ Cape Town, Infect Dis Inst, ZA-7925 Cape Town, South Africa

[3] Armauer Hansen Res Inst, Addis Ababa, Ethiopia

[4] Cape Technikon, Cape Town, South Africa

[5] Biomed Res Fdn, Matzingen, Switzerland

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 10期

关键词：

toll-like receptors; mycobacterium tuberculosis infection; lipoarabinomannan; bacterial lipoproteins;

D O I：

10.1016/j.micinf.2004.04.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The control of Mycobacterium tuberculosis infection depends on recognition of the pathogen and the activation of both the innate and adaptive immune responses. Toll-like receptors (TLR) were shown to play a critical role in the recognition of several pathogens. Mycobacterial antigens recognise distinct TLR resulting in rapid activation of cells of the innate immune system. Recent evidence from in vitro and in vivo investigations, summarised in this review demonstrates TLR-dependent activation of innate immune response, while the induction of adaptive immunity to mycobacteria may be TLR independent. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：946 / 959

页数：14

共 158 条

[1] Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice [J].