Guardian at the gate: preventing unspliced pre-mRNA export

被引：14

作者：

Casolari, JM

Silver, PA

机构：

[1] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

来源：

TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 05期

关键词：

D O I：

10.1016/j.tcb.2004.03.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The production of a mature mRNA requires the assembly and cooperation of numerous complexes before nuclear export. The deleterious effects of intron-containing pre-mRNA leakage into the cytoplasm necessitate mechanisms to prevent premature export of partially processed or unprocessed messages. A new study demonstrates that the Saccharomyces cerevisiae protein MIp1 specifically retains intron-containing pre-mRNAs in the nucleus.

引用

收藏

页码：222 / 225

页数：4

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