The remarkable role of water during the chemoselective reduction of ketones mediated by metallic aluminium

被引：13

作者：

Bhar, S ^{[1
]}

Guha, S ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Chem, Kolkata 700032, W Bengal, India

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 19期

关键词：

solvents and solvent effects; reduction; aluminium and compounds;

D O I：

10.1016/j.tetlet.2004.03.077

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diaryl ketones are reduced selectively to the corresponding benzhydrols in good yield by aluminium powder in the presence of sodium hydroxide in the solvent system MeOH:H2O = 2:1 whereas dialkyl ketones, alpha-tetralone, aryl alkyl ketones and cycloalkanones remain mostly unaffected. Interestingly, diaryl ketones remain totally unchanged by the present reagent combination in the absence of water, that is in anhydrous methanol. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3775 / 3777

页数：3

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