Recoverin as a paraneoplastic antigen in lung cancer: the occurrence of anti-recoverin autoantibodies in sera and recoverin in tumors

被引：53

作者：

Bazhin, AV

Savchenko, MS

Shifrina, ON

Demoura, SA

Chikina, SY

Jaques, G

Kogan, EA

Chuchalin, AG

Philippov, PP ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, AN Belozersky Inst Physicochem Biol, Biomed Labs, Dept Cell Signalling, Moscow 119992, Russia

[2] Pulmonol Res Inst, Moscow 105077, Russia

[3] IM Setchenov Moscow Med Acad, Chair Pathoanat, Moscow 119881, Russia

[4] Klinikum Philipps Univ, Klin Hamatol Onkol & Immunol, D-35033 Marburg, Germany

来源：

LUNG CANCER | 2004年 / 44卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

recoverin; non-small cell lung carcinoma; small cell lung carcinoma; cancer-associated retinopathy; paraneoplastic antigen; paraneoplastic neurological syndrome; autoimmunity;

D O I：

10.1016/j.lungcan.2003.10.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using immunoblotting with recombinant recoverin as an antigen, we have examined 279 serum samples from individuals with small cell lung carcinoma (SCLC, 99 patients), non-small cell lung carcinoma (NSCLC, 44 patients), and non-malignant pulmonary disorders (86 patients) as welt as sera from 50 healthy donors. Autoantibodies against recoverin (anti-Rc) were detected in sera from 15 patients with SCLC (15% of cases) and from 9 patients with NSCLC (about 20% of cases). Only two anti-Rc positive cases were detected in patients with non-malignant pulmonary disorders, white no such cases were found in healthy individuals. Immunohistochemical investigation of paraffin sections of 44 SCLC and 40 NSCLC tumors revealed recoverin-positive reaction in 30 SCLC (68%) and 34 NSCLC (85%) sections. Despite the high specificity (98%), the low sensitivity (Less than 20%) does not allow serum anti-Rc to be considered as a valuable marker of lung cancer. However, taking into account the high occurrence of aberrant expression of recoverin in lung tumors, this PNA could be considered as a potential target for immunotherapy of lung cancer. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：193 / 198

页数：6

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