Synthesis of 5(20)deoxydocetaxel, a new active docetaxel analogue

被引：33

作者：

Dubois, J ^{[1
]}

Thoret, S ^{[1
]}

Guéritte, F ^{[1
]}

Guénard, D ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 18期

关键词：

taxoids; docetaxel; oxetane; 10-deacetyl baccatin III; microtubules;

D O I：

10.1016/S0040-4039(00)00379-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5(20)Deoxydocetaxel was prepared from 13-oxo-10-deacetyl baccatin III. This compound is the first docetaxel analogue with a modified D-ring which is as active as paclitaxel on microtubules. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3331 / 3334

页数：4

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