2-MONOSUBSTITUTED-1,3-OXAZOLIDINES AS IMPROVED PROTECTIVE GROUPS OF N-BOC-PHENYLISOSERINE IN DOCETAXEL PREPARATION

被引：57

作者：

DIDIER, E

FOUQUE, E

TAILLEPIED, I

COMMERCON, A

机构：

[1] Rhône-Poulenc Rorer S.A.- Centre de Recherches de Vitry-Alfortville 13, 94403 Vitry-sur-Seine

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 15期

关键词：

D O I：

10.1016/0040-4039(94)85217-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new route for semisynthetic docetaxel, 1, is described using 2-monosubstituted-4-phenyl-1,3-oxazolidine-5-carboxylic acids in esterification of 7,10-O-diTroc-10-desacetylbaccatin III (4). Subsequent deprotection of esters 10(+10') afforded title compound 1 without removal of the Boc group.

引用

页码：2349 / 2352

页数：4

共 9 条

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