2-MONOSUBSTITUTED-1,3-OXAZOLIDINES AS IMPROVED PROTECTIVE GROUPS OF N-BOC-PHENYLISOSERINE IN DOCETAXEL PREPARATION

被引:57
作者
DIDIER, E
FOUQUE, E
TAILLEPIED, I
COMMERCON, A
机构
[1] Rhône-Poulenc Rorer S.A.- Centre de Recherches de Vitry-Alfortville 13, 94403 Vitry-sur-Seine
关键词
D O I
10.1016/0040-4039(94)85217-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new route for semisynthetic docetaxel, 1, is described using 2-monosubstituted-4-phenyl-1,3-oxazolidine-5-carboxylic acids in esterification of 7,10-O-diTroc-10-desacetylbaccatin III (4). Subsequent deprotection of esters 10(+10') afforded title compound 1 without removal of the Boc group.
引用
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页码:2349 / 2352
页数:4
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