CONFORMATIONALLY RESTRICTED P1-P1' TRANSITION-STATE ANALOGS - SYNTHESIS OF 1(R), 3(R) [1(S), 2(S)] AND 1(S), 3(S) [1(S), 2(S)] 3-[3-CYCLOHEXYL-2-[(BOC)AMINO]-1-HYDROXYPROPYL]-2,2-DIMETHYLCYCLOPROPANE CARBOXYLIC-ACIDS

被引:20
作者
MELNICK, MJ [1 ]
BISAHA, SN [1 ]
GAMMILL, RB [1 ]
机构
[1] UPJOHN CO,RES LABS,KALAMAZOO,MI 49001
关键词
D O I
10.1016/S0040-4039(00)94403-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A concise synthesis and determination of absolute stereochemistry of two novel diastereomeric cyclopropyl containing transition state mimics is described. © 1990.
引用
收藏
页码:961 / 964
页数:4
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共 19 条
  • [1] RENIN INHIBITORS CONTAINING HYDROPHILIC GROUPS - TETRAPEPTIDES WITH ENHANCED AQUEOUS SOLUBILITY AND NANOMOLAR POTENCY
    BOCK, MG
    DIPARDO, RM
    EVANS, BE
    FREIDINGER, RM
    RITTLE, KE
    PAYNE, LS
    BOGER, J
    WHITTER, WL
    LAMONT, BI
    ULM, EH
    BLAINE, EH
    SCHORN, TW
    VEBER, DF
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (10) : 1918 - 1923
  • [2] NOVEL RENIN INHIBITORS CONTAINING THE AMINO-ACID STATINE
    BOGER, J
    LOHR, NS
    ULM, EH
    POE, M
    BLAINE, EH
    FANELLI, GM
    LIN, TY
    PAYNE, LS
    SCHORN, TW
    LAMONT, BI
    VASSIL, TC
    STABILITO, II
    VEBER, DF
    RICH, DH
    BOPARI, AS
    [J]. NATURE, 1983, 303 (5912) : 81 - 84
  • [3] RENIN INHIBITORS - SYNTHESES OF SUBNANOMOLAR, COMPETITIVE, TRANSITION-STATE ANALOG INHIBITORS CONTAINING A NOVEL ANALOG OF STATINE
    BOGER, J
    PAYNE, LS
    PERLOW, DS
    LOHR, NS
    POE, M
    BLAINE, EH
    ULM, EH
    SCHORN, TW
    LAMONT, BI
    LIN, TY
    KAWAI, M
    RICH, DH
    VEBER, DF
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (12) : 1779 - 1790
  • [4] BUHLMAYER P, 1988, J MED CHEM, V31, P1839
  • [5] CARPINO P, 1986, TETRAHEDRON LETT, P2095
  • [6] SYNTHESES OF C-14-LABELLED (+)-TRANS-CHRYSANTHEMUM MONO-CARBOXYLIC AND DI-CARBOXYLIC ACIDS, AND OF RELATED COMPOUNDS
    CROMBIE, L
    DOHERTY, CF
    PATTENDE.G
    [J]. JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1970, (08): : 1076 - &
  • [7] OPTIMIZATION AND INVIVO EVALUATIONS OF A SERIES OF SMALL, POTENT, AND SPECIFIC RENIN INHIBITORS CONTAINING A NOVEL LEU-VAL REPLACEMENT
    DELLARIA, JF
    MAKI, RG
    BOPP, BA
    COHEN, J
    KLEINERT, HD
    LULY, JR
    MERITS, I
    PLATTNER, JJ
    STEIN, HH
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (11) : 2137 - 2144
  • [8] DOYLE MP, 1981, SYNTHESIS-STUTTGART, P781
  • [9] HRUBY VJ, 1985, TRENDS PHARMACOL SCI, P259
  • [10] INHIBITION OF RENIN BY SUBSTRATE-ANALOG INHIBITORS CONTAINING THE OLEFINIC AMINO-ACID 5(S)-AMINO-7-METHYL-3(E)-OCTENOIC ACID
    JOHNSON, RL
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (10) : 1351 - 1354