DNA Editing by APOBECs: A Genomic Preserver and Transformer

被引：60

作者：

Knisbacher, Binyamin A. ^{[1
]}

Gerber, Doron ^{[1
]}

Levanon, Erez Y. ^{[1
]}

机构：

[1] Bar Ilan Univ, Fac Life Sci, Mina & Everard Goodman, IL-52900 Ramat Gan, Israel

来源：

TRENDS IN GENETICS | 2016年 / 32卷 / 01期

基金：

欧洲研究理事会;

关键词：

INDUCED CYTIDINE DEAMINASE; B MESSENGER-RNA; CYTOSINE DEAMINATION; RESTRICTION FACTORS; SEQUENCING REVEALS; ENZYME APOBEC1; LINE-1; RETROTRANSPOSITION; AID/APOBEC FAMILY; FOREIGN DNA; C-MYC;

D O I：

10.1016/j.tig.2015.10.005

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Information warfare is not limited to the cyber world because it is waged within our cells as well. The unique AID (activation-induced cytidine deaminase)/APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide) family comprises proteins that alter DNA sequences by converting deoxycytidines to deoxyuridines through deamination. This C-to-U DNA editing enables them to inhibit parasitic viruses and retrotransposons by disrupting their genomic content. In addition to attacking genomic invaders, APOBECs can target their host genome, which can be beneficial by initiating processes that create antibody diversity needed for the immune system or by accelerating the rate of evolution. AID can also alter gene regulation by removing epigenetic modifications from genomic DNA. However, when uncontrolled, these powerful agents of change can threaten genome stability and eventually lead to cancer.

引用

页码：16 / 28

页数：13

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