The genetics of primary open-angle glaucoma: A review

被引：184

作者：

Allingham, R. Rand ^{[1
]}

Liu, Yutao ^{[2
]}

Rhee, Douglas J. ^{[3
]}

机构：

[1] Duke Univ, Ctr Eye, Durham, NC 27710 USA

[2] Duke Univ, Duke Ctr Human Genet, Durham, NC 27710 USA

[3] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Boston, MA USA

来源：

EXPERIMENTAL EYE RESEARCH | 2009年 / 88卷 / 04期

关键词：

POAG; genetics; genetic linkage; whole genome association; admixture mapping; genetic screening; myocilin; optineurin; WDR36; SNP; NORMAL-TENSION GLAUCOMA; WIDE SCAN MAPS; OPTINEURIN SEQUENCE VARIATIONS; INCREASES OUTFLOW RESISTANCE; HUMAN TRABECULAR MESHWORK; NITRIC-OXIDE SYNTHASE; S-TRANSFERASE M1; MYOCILIN MUTATIONS; INTRAOCULAR-PRESSURE; CLINICAL-FEATURES;

D O I：

10.1016/j.exer.2008.11.003

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Glaucoma is the major cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), as the most prevalent form of glaucoma, is a complex inherited disorder and affects more than 2 million individuals in the United States. It has become increasingly clear that a host of genetic as well as environmental factors are likely to contribute to the phenotype. A number of chromosomal and genetic associations have been reported for POAG. This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：837 / 844

页数：8

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