(99m)Technetium-stannous oxinate as marker of liposome formulations

被引：5

作者：

Alafandy, M ^{[1
]}

Goffinet, G ^{[1
]}

Umbrain, V ^{[1
]}

DHaese, J ^{[1
]}

Camu, F ^{[1
]}

Legros, FJ ^{[1
]}

机构：

[1] UNIV LIEGE,LAB GEN BIOL & ULTRASTRUCT MORPHOL,B-6040 LIEGE,BELGIUM

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1996年 / 23卷 / 07期

关键词：

Tc-99m stannous oxinate liposomes; multilamellar vesicles; small unilamellar vesicles; liposome characterization; liposome stability;

D O I：

10.1016/S0969-8051(96)00118-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Liposomes associated with tin(II) dioxinate were prepared from egg yolk phosphatidylcholine and cholesterol as sterile and pyrogen free multilamellar or unilamellar vesicles. Complexing of liposomal tin(II) dioxinate with Tc-99m attained 98% of the added radioactivity. Thirty percent Tc-99m were released during 24-h incubation in biological fluids. The absence of tin colloids seen by electron microscopy and the stability of liposomal phospholipid and tin(II) dioxinate during 72-h incubation at 37 degrees C in plasma and cerebrospinal fluid would allow safe and reliable scintigraphic liposome pharmacokinetic studies. Copyright (C) 1996 Elsevier Science Inc.

引用

页码：881 / 887

页数：7

共 33 条

[1]

ANGHILERI LJ, 1976, J NUCL BIOL MED, V20, P165

[2]

ANGHILERI LJ, 1977, EUR J NUCL MED, V2, P109

[3]

ASAKAWA T, 1980, LIPIDS, V15, P137, DOI 10.1007/BF02540959

[4]

Barenholz Y., 1993, LIPOSOME TECHNOLOGY, P527

[5]

Barratt GM, 1984, LIPOSOME TECHNOLOGY, V1, P93

[6]

BEGATERI GV, 1993, LIPOSOME DRUG DELIVE, P29

[7] REMYELINATION IN SPINAL-CORD OF CAT FOLLOWING INTRASPINAL INJECTIONS OF LYSOLECITHIN [J].

BLAKEMORE, WF ;

EAMES, RA ;

SMITH, KJ ;

MCDONALD, WI .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1977, 33 (1-2) :31-43

[8]

Boogaerts J, 1995, Acta Anaesthesiol Belg, V46, P19

[9] EPIDURAL ADMINISTRATION OF LIPOSOME-ASSOCIATED BUPIVACAINE FOR THE MANAGEMENT OF POSTSURGICAL PAIN - A FIRST-STUDY [J].

BOOGAERTS, JG ;

LAFONT, ND ;

DECLERCQ, AG ;

LUO, HC ;

GRAVET, ET ;

BIANCHI, JA ;

LEGROS, FJ .

JOURNAL OF CLINICAL ANESTHESIA, 1994, 6 (04) :315-320

[10] TECHNICAL AND BIOLOGICAL CONSIDERATIONS ON THE USE OF RADIOLABELED LIPOSOMES FOR DIAGNOSTIC-IMAGING [J].

CARIDE, VJ .

NUCLEAR MEDICINE AND BIOLOGY, 1990, 17 (01) :35-39

← 1 2 3 4 →