(99m)Technetium-stannous oxinate as marker of liposome formulations

被引：5

作者：

Alafandy, M ^{[1
]}

Goffinet, G ^{[1
]}

Umbrain, V ^{[1
]}

DHaese, J ^{[1
]}

Camu, F ^{[1
]}

Legros, FJ ^{[1
]}

机构：

[1] UNIV LIEGE,LAB GEN BIOL & ULTRASTRUCT MORPHOL,B-6040 LIEGE,BELGIUM

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1996年 / 23卷 / 07期

关键词：

Tc-99m stannous oxinate liposomes; multilamellar vesicles; small unilamellar vesicles; liposome characterization; liposome stability;

D O I：

10.1016/S0969-8051(96)00118-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Liposomes associated with tin(II) dioxinate were prepared from egg yolk phosphatidylcholine and cholesterol as sterile and pyrogen free multilamellar or unilamellar vesicles. Complexing of liposomal tin(II) dioxinate with Tc-99m attained 98% of the added radioactivity. Thirty percent Tc-99m were released during 24-h incubation in biological fluids. The absence of tin colloids seen by electron microscopy and the stability of liposomal phospholipid and tin(II) dioxinate during 72-h incubation at 37 degrees C in plasma and cerebrospinal fluid would allow safe and reliable scintigraphic liposome pharmacokinetic studies. Copyright (C) 1996 Elsevier Science Inc.

引用

页码：881 / 887

页数：7

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