Pili prove pertinent to entrococcal endocarditis

被引：11

作者：

Budzik, Jonathan M. ^{[1
]}

Schneewind, Olaf ^{[1
]}

机构：

[1] Univ Chicago, Dept Microbiol, Chicago, IL 60637 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2006年 / 116卷 / 10期

关键词：

D O I：

10.1172/JCI30088

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Enterococcus faecalis is an important agent of endocarditis and urinary tract infections, which occur frequently in hospitals. Antimicrobial therapy is complicated by the emergence of drug-resistant strains, which contribute significantly to mortality associated with E. faecafs infection. In this issue of the JCI, Nallapareddy and colleagues report that E. faecalis produces pili on its surface and that these proteinaceous fibers are used for bacterial adherence to host tissues and for the establishment of biofilms and endocarditis (see the related article beginning on page 2799). This information may enable new vaccine strategies for the prevention of E. faecafs infections.

引用

页码：2582 / 2584

页数：3

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