Renal granuloma and immunoglobulin M-complex glomerulonephritis: a case of common variable immunodeficiency?

被引：9

作者：

Benoit, Genevieve ^{[1
]}

Lapeyraque, Anne-Laure ^{[1
]}

Sartelet, Herve ^{[2
]}

Saint-Cyr, Claire ^{[3
]}

Le Deist, Francoise ^{[4
]}

Haddad, Elie ^{[5
]}

机构：

[1] Univ Montreal, CHU St Justine, Dept Pediat, Div Nephrol, Montreal, PQ H3T 1C5, Canada

[2] Univ Montreal, CHU St Justine, Dept Pathol, Montreal, PQ H3T 1C5, Canada

[3] Univ Montreal, CHU St Justine, Dept Pediat, Div Rheumatol, Montreal, PQ H3T 1C5, Canada

[4] Univ Montreal, CHU St Justine, Dept Microbiol & Immunol, Montreal, PQ H3T 1C5, Canada

[5] Univ Montreal, CHU St Justine, Dept Pediat, Div Immunol, Montreal, PQ H3T 1C5, Canada

来源：

PEDIATRIC NEPHROLOGY | 2009年 / 24卷 / 03期

关键词：

Renal granuloma; Common variable immunodeficiency; IgM deposits; Mesangial proliferation; Sarcoidosis; MONOCLONAL-ANTIBODY TREATMENT; INTERSTITIAL NEPHRITIS; PATIENT; HYPOGAMMAGLOBULINEMIA; COMPLICATIONS; DISEASE;

D O I：

10.1007/s00467-008-0958-z

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

Common variable immunodeficiency (CVID) is characterized by reduced serum immunoglobulin levels and recurrent bacterial infections. Granulomatous infiltrations are occasionally found in the lymphoid or solid organs of affected patients, but renal involvement is rare. We present a case of possible CVID with interstitial noncaseating granuloma and immunoglobulin (IgM)-complex glomerulonephritis with a membranoproliferative pattern and with a favorable response to corticosteroids, intravenously administered immunoglobulins (IVIGs) and rituximab. CVID must be included in the differential diagnosis of renal granuloma and should be differentiated from sarcoidosis to ensure appropriate therapy.

引用

页码：601 / 604

页数：4

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