Overexpression of the RNA polymerase alpha subunit reduces transcription of Bvg-activated virulence genes in Bordetella pertussis

被引：7

作者：

Carbonetti, NH ^{[1
]}

Romashko, A ^{[1
]}

Irish, TJ ^{[1
]}

机构：

[1] Univ Maryland, Sch Dent, Dept Microbiol, Baltimore, MD 21201 USA

来源：

JOURNAL OF BACTERIOLOGY | 2000年 / 182卷 / 02期

关键词：

D O I：

10.1128/JB.182.2.529-531.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Overexpression of the RNA polymerase alpha subunit in Bordetella pertussis reduces expression of the virulence factor pel tussis toxin, Here me show that this reduction is at the level of transcription, is reversed by overexpression of the transcriptional activator BvgA, and is dependent on the C-terminal domain of alpha.

引用

页码：529 / 531

页数：3

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