A 32-channel time-resolved instrument for medical optical tomography

被引:205
作者
Schmidt, FEW [1 ]
Fry, ME [1 ]
Hillman, EMC [1 ]
Hebden, JC [1 ]
Delpy, DT [1 ]
机构
[1] UCL, Dept Med Phys & Bioengn, London WC1E 6JA, England
关键词
D O I
10.1063/1.1150191
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
A prototype multichannel time-resolved medical optical tomography system is presented, and various instrumental aspects and performance issues are discussed. The instrument has been designed primarily as a continuous bedside monitor for obtaining functional images of premature infants' brains that are at an increased risk of injury due to dysfunction in cerebral oxygenation or hemodynamics. Separate maps of the internal absorption and scattering properties can be reconstructed from purely temporal measurements of photons transmitted diffusely through the tissue, and without recourse to reference or baseline measurements. The instrument employs 32 source fibers that sequentially deliver near-infrared pulsed laser radiation of picosecond duration. Transit time measurements of very high temporal resolution and stability are made between these sources and 32 detector optodes that are located on the surface. The effectiveness of this instrument is demonstrated by successfully imaging a tissue-equivalent phantom. (C) 2000 American Institute of Physics. [S0034-6748(00)02001-3].
引用
收藏
页码:256 / 265
页数:10
相关论文
共 29 条
[1]   Optical imaging in medicine .2. Modelling and reconstruction [J].
Arridge, SR ;
Hebden, JC .
PHYSICS IN MEDICINE AND BIOLOGY, 1997, 42 (05) :841-853
[2]   Optical tomography in medical imaging [J].
Arridge, SR .
INVERSE PROBLEMS, 1999, 15 (02) :R41-R93
[3]   Nonuniqueness in diffusion-based optical tomography [J].
Arridge, SR ;
Lionheart, WRB .
OPTICS LETTERS, 1998, 23 (11) :882-884
[4]  
ARRIDGE SR, UNPUB INT J IMAGING
[5]   Imaging with electricity: Report of the European Concerted Action on Impedance Tomography [J].
Boone, K ;
Barber, D ;
Brown, B .
JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY, 1997, 21 (06) :201-232
[6]  
BRIGHT R, 1831, PATERNOSTER ROW LOND, V2, P431
[7]   Optical investigations of physiology: A study of intrinsic and extrinsic biomedical contrast [J].
Chance, B ;
Luo, QM ;
Nioka, S ;
Alsop, DC ;
Detre, JA .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1997, 352 (1354) :707-716
[8]   Tomographic image reconstruction from optical projections in light-diffusing media [J].
Colak, SB ;
Papaioannou, DG ;
tHooft, GW ;
vanderMark, MB ;
Schomberg, H ;
Paasschens, JCJ ;
Melissen, JBM ;
vanAsten, NAAJ .
APPLIED OPTICS, 1997, 36 (01) :180-213
[9]   SYSTEM FOR LONG-TERM MEASUREMENT OF CEREBRAL BLOOD AND TISSUE OXYGENATION ON NEWBORN-INFANTS BY NEAR-INFRARED TRANS-ILLUMINATION [J].
COPE, M ;
DELPY, DT .
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1988, 26 (03) :289-294
[10]   Quantification in tissue near-infrared spectroscopy [J].
Delpy, DT ;
Cope, M .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1997, 352 (1354) :649-659