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A novel extended-spectrum TEM-type β-lactamase, TEM-138, from Salmonella enterica serovar infantis

被引：16
作者：
Chouchani, Chedly
Berlemont, Renaud
Masmoudi, Afef
Galleni, Moreno
Frere, Jean-Marie
Belhadj, Omrane
Ben-Mahrez, Kamel
机构：
[1] Fac Sci Tunis, Lab Biochim & Biotechnol, Tunis 2092, Tunisia
[2] Univ Liege, Lab Macromol Biol, Ctr Ingn Prot, B-4000 Sart Tilman Par Liege, Belgium
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 09期
关键词：
D O I：
10.1128/AAC.00388-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A novel natural TEM beta-lactamase with extended-spectrum activity, TEM-138, was identified in a ceftazidime-resistant clinical isolate of Salmonella enterica serovar Infantis. Compared to TEM-1, TEM-138 contains the following mutations: E104K, N1751, and G238S. The bla(TEM-138) gene was located on a 50-kb transferable plasmid. Expression studies with Escherichia coli revealed efficient ceftazidimase and cefotaximase activities for TEM-138.
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收藏
页码：3183 / 3185
页数：3
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