Molecular mapping of the recognition interface between the islet amyloid polypeptide and insulin

被引：77

作者：

Gilead, Sharon ^{[1
]}

Wolfenson, Haguy ^{[1
]}

Gazit, Ehud ^{[1
]}

机构：

[1] Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 39期

关键词：

amyloids; insulin; molecular recognition; peptides; protein-protein interactions;

D O I：

10.1002/anie.200602034

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Nature's route for amyloid prevention: Insulin is a natural inhibitor of amyloid formation by the islet amyloid polypeptide (IAPP). The interacting domains of both proteins were identified by using a reductionist approach (see scheme). An understanding of the molecular mechanism of this physiological interaction may lead to the design of peptidomimetic drugs for type II diabetes. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6476 / 6480

页数：5

共 29 条

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