Anticipating the $1,000 genome

被引:103
作者
Mardis, Elaine R. [1 ]
机构
[1] Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
关键词
D O I
10.1186/gb-2006-7-7-112
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A new generation of DNA-sequencing platforms will become commercially available over the next few years. These instruments will enable re-sequencing of human genomes at a previously unimagined throughput and low cost. Here, I examine why the $1,000 human genome is an important goal for research and clinical diagnostics, and what will be required to achieve it.
引用
收藏
页数:5
相关论文
共 16 条
[11]  
Robertson JA., 2003, AM J BIOETHICS, V3, pW, DOI DOI 10.1162/152651603322874762
[12]   Real-time DNA sequencing using detection of pyrophosphate release [J].
Ronaghi, M ;
Karamohamed, S ;
Pettersson, B ;
Uhlen, M ;
Nyren, P .
ANALYTICAL BIOCHEMISTRY, 1996, 242 (01) :84-89
[13]   A sequencing method based on real-time pyrophosphate [J].
Ronaghi, M ;
Uhlén, M ;
Nyrén, P .
SCIENCE, 1998, 281 (5375) :363-+
[14]   MOLECULAR STRUCTURE OF NUCLEIC ACIDS - A STRUCTURE FOR DEOXYRIBOSE NUCLEIC ACID [J].
WATSON, JD ;
CRICK, FHC .
NATURE, 1953, 171 (4356) :737-738
[15]   Mutational profiling in the human genome [J].
Wilson, RK ;
Ley, TJ ;
Cole, FS ;
Milbrandt, JD ;
Clifton, S ;
Fulton, L ;
Fewell, G ;
Minx, P ;
Sun, H ;
McLellan, M ;
Pohl, C ;
Mardis, ER .
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2003, 68 :23-29
[16]   Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome [J].
Woloszynek, JR ;
Rothbaum, RJ ;
Rawls, AS ;
Minx, PJ ;
Wilson, RK ;
Mason, PJ ;
Bessler, M ;
Link, DC .
BLOOD, 2004, 104 (12) :3588-3590