Trends affecting the future of vaccine development and delivery: The role of demographics, regulatory science, the anti-vaccine movement, and vaccinomics

被引：76

作者：

Poland, Gregory A. ^{[1
,2
,3
]}

Jacobson, Robert M. ^{[1
,4
]}

Ovsyannikova, Inna G. ^{[1
,2
,3
]}

机构：

[1] Mayo Clin, Mayo Vaccine Res Grp, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Internal Med, Rochester, MN 55905 USA

[3] Mayo Clin, Program Translat Immunovirol & Biodef, Rochester, MN 55905 USA

[4] Mayo Clin, Dept Pediat & Adolescent Med, Rochester, MN 55905 USA

来源：

VACCINE | 2009年 / 27卷 / 25-26期

关键词：

Vaccinomics; Vaccine future; Vaccine; Anti-vaccine; Randomized clinical trials; Gene polymorphisms; HUMAN-LEUKOCYTE ANTIGEN; CLASS-II ALLELES; IMMUNE-RESPONSES; MEASLES-VACCINE; EMERGING FIELD; IMMUNOGENETICS; POPULATION; SAFETY; IMMUNOGENICITY; POLYMORPHISMS;

D O I：

10.1016/j.vaccine.2009.01.069

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Important scientific, Cultural, temporal, and secular issues impact the development of, and delivery of vaccines. In this paper we discuss the impact of demographics, regulatory science, the anti-vaccine movement, and finally the impact of the new biology and individualized medicine, which we call vaccinomics, on vaccine development and delivery. A description of the issues and how they have, are, or should be impacting vaccinology is provided, and hopefully will result in increased attention and discussion among vaccinologists. These issues have been under-valued, under-discussed, and in some cases, ignored. We hope that discussion of these issues will result in changes in how we develop, and how we Communicate those developments, to the public. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3240 / 3244

页数：5

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