Serum interleukin-17 levels are related to clinical severity in allergic rhinitis

被引：114

作者：

Ciprandi, G. ^{[1
]}

De Amici, M. ^{[2
]}

Murdaca, G. ^{[1
]}

Fenoglio, D. ^{[1
]}

Ricciardolo, F. ^{[3
]}

Marseglia, G. ^{[2
]}

Tosca, M. ^{[4
]}

机构：

[1] Univ Genoa, Dept Internal Med, Azienda Osped Univ San Martino, I-16126 Genoa, Italy

[2] Univ Pavia, Pediat Clin, Fdn IRCCS San Matteo, Dept Pediat Sci, I-27100 Pavia, Italy

[3] Univ Turin, Dept Resp Dis, Turin, Italy

[4] Ist Giannina Gaslini, Allergy Ctr, I-16148 Genoa, Italy

来源：

ALLERGY | 2009年 / 64卷 / 09期

关键词：

allergen exposure; allergic rhinitis; allergy severity; interleukin-17; pollen season; IL-17;

D O I：

10.1111/j.1398-9995.2009.02010.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: T helper (Th)-17 cells are a subset of T helper lymphocytes that exert regulatory activities. Recently, it has been reported that serum interleukin (IL)-17 levels are high in the most severe cases of birch allergy studied outside the pollen season. Objective: The aim of this study was to investigate a possible relationship between serum IL-17 levels and clinical parameters in patients with allergic rhinitis studied during the pollen season. Methods: In all, 56 patients with persistent pollen-induced allergic rhinitis were evaluated during the pollen season. Serum IL-17 levels were evaluated by enzyme-linked immunosorbent assay. Symptoms were assessed by visual analogue scale, drug use was monitored and peripheral eosinophils were counted. Results: Serum IL-17 levels were significantly related to clinical symptoms, drug use and peripheral eosinophil counts (P = 0.0001 for all). Conclusion: This study provides evidence that serum IL-17 level assessment might be considered to classify allergy severity.

引用

页码：1375 / 1378

页数：4

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