The hypoblast of the chick embryo positions the primitive streak by antagonizing nodal signaling

被引:124
作者
Bertocchini, F [1 ]
Stern, CD [1 ]
机构
[1] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England
关键词
D O I
10.1016/S1534-5807(02)00318-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The hypoblast (equivalent to the mouse anterior visceral endoderm) of the chick embryo plays a role in regulating embryonic polarity. Surprisingly, hypoblast removal causes multiple embryonic axes to form, suggesting that it emits an inhibitor of axis formation. We show that Cerberus (a multifunctional antagonist of Nodal, Wnt, and BMP signaling) is produced by the hypoblast and inhibits primitive streak formation. This activity is mimicked by Cerberus-Short (CerS), which only inhibits Nodal. Nodal misexpression can initiate an ectopic primitive streak, but only when the hypoblast is removed. We propose that, during normal development, the primitive streak forms only when the hypoblast is displaced away from the posterior margin by the endoblast, which lacks Cerberus.
引用
收藏
页码:735 / 744
页数:10
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