Diacyllipid-polymer micelles as nanocarriers for poorly soluble anticancer drugs

被引：224

作者：

Gao, ZG ^{[1
]}

Lukyanov, AN ^{[1
]}

Singhal, A ^{[1
]}

Torchilin, VP ^{[1
]}

机构：

[1] Northeastern Univ, Bouve Coll Hlth Sci, Dept Pharmaceut Sci, Boston, MA 02115 USA

来源：

NANO LETTERS | 2002年 / 2卷 / 09期

关键词：

D O I：

10.1021/nl025604a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly stable micelles with the size of 10 to 40 nm can be prepared from poly(ethylene glycol)/phosphatidyl ethanolamine (PEG-PE) conjugates. These micelles easily solubilize and firmly retain substantial quantities of various poorly soluble anticancer drugs (m-porphyrin, tamoxifen, taxol). The micelles with encapsulated drugs have the size and size distribution very close to that of original "empty" micelles. Stable drug-loaded polymeric micelles may represent a convenient drug delivery system into tumors utilizing the enhanced permeability and retention (EPR) effect.

引用

页码：979 / 982

页数：4

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